Viral Vector Process Development and Optimization

With over 60 products manufactured, we offer extensive experience transferring in, establishing, and optimizing viral vector processes. Development of cell culture processes to support:

• Suspension: 50L to 2000L single-use bioreactors
• Adherent: Flatstock and iCELLis® platforms

Purification capabilities:

• Platform purification processes offered for all vector types
• Single-use / non-product contact equipment
• Depth, TFF and other filtration methods for harvest and concentration
• Broad range of chromatography solutions: Affinity, SEC, IEX, and HIC
• Viral inactivation and clearance studies
• Optimization as needed for:
  • Increasing yield / recovery
  • Full capsid separation
  • Specific purity requirements

Available services:

• Customized transfection and infection parameters as necessary
• Multiple 2L and iCELLis® NANO bioreactors for bioreactor development and optimization
• Multiple 50L and 200L bioreactors for scale up and pre-clinical material production
• ambr® 15 for DoE studies and rapid development
• Custom media optimization, production, sourcing, and testing
• Manifolding for plate-based development
• Partitioning studies

Question? We’re Here to Help.

Please contact us to learn more about our viral vector development and clinical services.