Viral Vector Process Development and Optimization
With over 60 products manufactured, we offer extensive experience transferring in, establishing, and optimizing viral vector processes. Development of cell culture processes to support:
- Suspension: 50L to 2000L single-use bioreactors
- Adherent: Flatstock and iCELLis® platforms
Purification capabilities:
- Platform purification processes offered for all vector types
- Single-use / non-product contact equipment
- Depth, TFF and other filtration methods for harvest and concentration
- Broad range of chromatography solutions: Affinity, SEC, IEX, and HIC
- Viral inactivation and clearance studies
- Optimization as needed for:
- Increasing yield / recovery
- Full capsid separation
- Specific purity requirements
Available services:
- Customized transfection and infection parameters as necessary
- Multiple 2L and iCELLis® NANO bioreactors for bioreactor development and optimization
- Multiple 50L and 200L bioreactors for scale up and pre-clinical material production
- ambr® 15 for DoE studies and rapid development
- Custom media optimization, production, sourcing, and testing
- Manifolding for plate-based development
- Partitioning studies
Question? We’re Here to Help.
Please contact us to learn more about our viral vector development and clinical services.