St. Louis, Missouri

St. Louis, MOThe Thermo Fisher Scientific St. Louis facility offers full mammalian cell process development including late stage characterization and process validation to support clinical (Phase I-III) to commercial manufacturing.

Specialized Capabilities

Analytical Laboratory Capabilities

  • Chromatography: affinity, lEX, SEC, HIC, RP, peptide mapping
  • MW determination by mass spectrometry
  • Electrophoresis: SDS-PAGE densitometry & IEF
  • Sequence confirmation and PTM/degradation by LC-MS/MS
  • Potency: binding ELISA, enzymatic activity assays,cell-based potency assay
  • Aggregates by SEC-MALS
  • Impurity: residual Protein A, HCP, residual DNA
  • Subvisible particles by LO
  • Quantity: protein A/G HPLC, ELISA titer assay, A280
  • Amino Acid Analysis by UPLC
  • Capillary electrophoresis (CE-SDS, cIEF, CE-LIF)
  • Extinction Coefficient determination
  • DOE for method development and method validation
  • N-Glycan profiling by fluorescence-labeling and normal phase HPLC or CE
  • Protein conformation characterization using capillary DSC
  • Sialic acid content and NANA/NAGA ratio measurement
  • High throughput CE-SDS and glycan profiling with microfluidic instrument
  • Monosaccharide Analysis
  • Charged Aerosol Detector (CAD) used to test Polysorbate, Anti-foam, Pluronic

This site features a strong regulatory inspection history from all major regulatory agencies.

Learn more about the specific equipment and capabilities at this site by downloading our Site Fact Sheet.


Resource Downloads

Site Capabilities Fact Sheet
Visiting St. Louis

St. Louis, MO

4766 LaGuardia Drive
St. Louis, MO 63134-3117

+1 314 426 5000